Ocular effects of chlorpromazine and oxypertine on beagle dogs.

Abstract

Ocular abnormalities induced by phenothiazine medication have been reported in man (Goar and Fletcher, I957; Grutzner, I969; Leinefelder and Burian, I964; Siddall, I965; Verrey, 1956) and reproduced experimentally in animals (Cerletti and Meier-Ruge, I968; McDonald, Snell and Lerner, I967; Reinert, and Rutty, I969; Smith, Gavitt, and Karmin, I966; Wagner, 1956; Weinstock and Scott, I967). Only a few of the papers published have dealt with electrophysiological changes in visual function (Boet, I969; Franceschetti, Franqois, and Babel, I964; Henkes, I967). In our experiments, we have tried to detect chlorpromazine-induced ocular changes in the dog and to follow their course after stopping the medication. The changes were compared with those possibly induced by oxypertine, a neuroleptic of a different chemical type. Before, during, and after medication we studied the eyes by means of the slit lamp, the ophthalmoscope, electroretinography, histopathology, and biochemical estimations.

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